SOMA® 250 mg Tolerability

SOMA 250 mg is well tolerated, with reduced drowsiness compared to SOMA® 350 mg.¹

Well Tolerated
SOMA 250 mg (carisoprodol) is generally well tolerated. Two double-blind, randomized, placebo-controlled, multicenter trials with over 1,300 patients showed²

• Less drowsiness: 13% of patients reported drowsiness
• Fewer discontinuations: SOMA 250 mg had 2% discontinuations vs 5.4% for SOMA 350 mg (vs 2.7% and 2.7% for placebo, respectively)

Incidence of Drowsiness With SOMA 250 mg (n=548)^{† 2}

†See Study Design.

Please see full Prescribing Information.

Common Side Effects
In clinical studies of SOMA 250 mg, the most common side effects were drowsiness, dizziness, and headache.²

Percent of Patients Reporting Side Effects in Controlled Studies^{† 2}

†See Study Design.

Please see full Prescribing Information.

Awareness of Drug Abuse and Dependence
Cases of dependence, withdrawal, and abuse have been reported with prolonged use. Most cases occurred in patients who:

• Had history of addiction
• Used SOMA in combination with other drugs with abuse potential

As a result of these findings, it is recommended to:

• Use for up to 2 or 3 weeks because adequate evidence of effectivenesss for more prolonged use is not available
• Use caution in prescribing carisoprodol to addiction-prone patients and patients taking other CNS depressants, including alcohol

Reference
(1) Data on file. Meda Healthcare, Inc.

(2) SOMA [package insert]. Somerset, NJ: Meda Healthcare Inc.; 2007.